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目的 观察头孢吡肟治疗骨科围术期医院获得性肺炎的疗效及安全性 ,并与头孢他啶进行比较。方法 骨科围术期医院获得性肺炎 70例随机分为两组 :头孢吡肟组 3 5例 ,静滴 1.0～ 2 .0g ,2次 /d ;头孢他啶组 3 5例 ,静滴 1.0～ 2 .0g ,2次 /d ;两组均治疗 1～ 2周。结果 头孢吡肟组及头孢他啶组临床有效率分别为 94.2 9%及 91.43 % (P >0 .0 5 ) ,细菌清除率分别为 94.12 %及 90 .91% (P >0 .0 5 ) ,不良反应发生率均为 2 .86% (P >0 .0 5 )。结论 头孢吡肟治疗骨科围术期医院获得性肺炎的疗效显著而又安全
Objective To observe the efficacy and safety of cefepime in the treatment of hospital-acquired pneumonia during orthopedic surgery and to compare with ceftazidime. Methods Seventy patients with hospital-acquired pneumonia under orthopedic surgery were randomly divided into two groups: cefepime group 35 cases, intravenous 1.0-2.0 g twice daily, ceftazidime group 35 cases and intravenous infusion 1.0-2. 0g, 2 times / d; two groups were treated for 1 to 2 weeks. Results The clinical efficiencies of cefepime group and ceftazidime group were 94.2 9% and 91.43%, respectively (P 0. 05). The bacterial clearance rates were 94.12% and 90.91%, respectively (P0.05) The response rate was 2.86% (P> 0.05). Conclusion The efficacy of cefepime in the treatment of hospital-acquired pneumonia during orthopedic surgery was significant and safe