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目的探讨慢性阻塞性肺疾病(COPD)稳定期急性加重期患者血清CRP水平的临床意义。方法2组患者分别在就诊或收住院当日抽取静脉血3m l,提取血清送检,CRP采用酶联免疫分析法测定,并进行组间及加重期组内CRP水平的分析。结果COPD急性加重期患者血清CRP水平显著高于COPD稳定期患者(P<0.01),而在AECOPD患者中死亡组血清CRP水平又显著高于存活组(P<0.001)。结论CRP升高不仅可以提示COPD的急性加重,极度升高又提示COPD患者病情严重并且可能预后不良。
Objective To investigate the clinical significance of serum CRP level in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Method 2 patients were treated on the day of admission or hospital blood venous withdrawal 3m l, serum was seized, CRP was measured by enzyme-linked immunosorbent assay, and intra-group and exacerbation of CRP level within the group analysis. Results Serum CRP level was significantly higher in COPD patients with acute exacerbation than that in patients with stable COPD (P <0.01). Serum levels of CRP in death patients were significantly higher than those in survivors (P <0.001). Conclusions Elevated CRP can not only prompt the acute exacerbation of COPD, but also indicate that COPD patients are in serious condition and may have poor prognosis.