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目的 解决急性早幼粒细胞白血病 (M3)目前国内因粗细颗粒混杂而造成的分型困难。方法 以粗颗粒型早幼粒细胞的百分率进行分型 ,规定 :粗颗粒型早幼粒细胞 >70 %为M 3a(粗颗粒型 ) ;30 % <粗颗粒型早幼粒细胞≤ 70 %为M3b(混合颗粒型 ) ;粗颗粒型早幼粒细胞≤ 30 %为M3c(细颗粒型 )。结果 三种亚型的发生率M 3a为 4 2 .31% ,M 3b为 30 .13% ,M 3c为 2 7.5 6 % ;性别分布M3a男性明显多于女性 ,M3b无性别差异 ,M3c女性明显多于男性 ;年龄分布M 3a 0 .0 5 )。淋巴结肿大以M3b为多 ,M3a次之 ,M3c未见肿大者。Hb、RBC、BPC、WBC的均值M3a M3a >M 3b ;骨髓有核细胞的增生M3a多为增生极度活跃 ,M3b、M 3c多为增生明显活跃 ;粒红比值、早幼粒细胞的百分率、粗颗粒型早幼粒细胞的比值均M 3a >M3b >M3c ;Auer小体的发生M 3b多见 ,M3c较少见 ,M 3a不易见。结论 三种亚型不论在性别、年龄分布上 ,还是在主?
Objective To solve the problem of acute promyelocytic leukemia (M3) due to the difficulty of typing caused by the coalescence of coarse and fine particles in China. The method was based on the percentage of coarse granular promyelocytic cells. It was stipulated that> 70% of coarse granular promyelocytic cells was M 3a (coarse granular type), and 30% <70% of coarse granular promyelocytic cells was M3b (mixed granular type); coarse granular promyelocytic ≤ 30% M3c (fine granular type). Results The incidence of three subtypes was 42.31%, M 3b was 30.13%, and M 3c was 7.56%. The distribution of M3a in male was more than that in female, M3b had no gender difference, and M3c was significantly More than males; age distribution M3a 0.05). M3b for lymph node enlargement, followed by M3a, M3c no enlargement. The mean values of M3b and Mc in peripheral blood were M3a> M3a> M3b. The proliferation of bone marrow nucleated cells was mostly hyperplastic, M3b and M3c M3b> M3c. The occurrence of Auer bodies was more common than M 3b, M3c was rare, and the ratio of M 3a to M3g was higher Not easy to see. Conclusion The three subtypes, regardless of gender, age distribution, or in the main?