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目的 :探讨感染性多脏器功能不全综合征 (MODS) /多脏衰 (MSOF)的中西医结合诊治方法 ,以提高本症抢救成功率。方法 :对急性感染并发MODS/MSOF住院患者 2 2 5例 ,进行原发疾病、并发症等的西医诊断和证型的中医辨证诊断 ,据此在全面西医西药治疗的基础上 ,应用中药以中西医结合方法治疗 ,并进行临床观察和中药治疗作用的机理研究。结果 :止于 1998年底共救治感染性MODS患者 2 2 5例 ,抢救成功 161例 ,死亡 64例 ,病死率 2 8 4 % ;其中MSOF 140例 ,死亡 58例 ,病死率为 4 1 4 % ,应用美国KnausWA教授MSOF诊断标准 ,本组符合者 10 6例 ,抢救成功 52例 ,死亡 54例 ,病死率为 50 9%。结论 :应用中西医结合方法治疗本综合征 ,疗效显著提高 ,在于中药可改善患者的血流动力学、血液流变学、甲襞微循环障碍 ;影响细胞因子、炎症介质水平 ,从而减轻全身性炎症反应 ,并可减轻胃肠运动功能的受抑制状态、肠道菌群失调及防治肠道细菌、内毒素移位 ;抗氧化保护细胞作用
OBJECTIVE: To explore the diagnosis and treatment of multiple organ dysfunction syndrome (MODS) / multiple dirty decay (MSOF) with integrated traditional Chinese and western medicine to improve the success rate of salvage. Methods: Twenty-five inpatients with MODS / MSOF complicated with acute infection were diagnosed with TCM diagnosis and syndrome differentiation of TCM syndromes. Based on the comprehensive western medicine treatment, Western medicine treatment methods, and clinical observation and treatment of traditional Chinese medicine mechanism of action. Results: A total of 225 cases of infectious MODS were treated and treated at the end of 1998, 161 cases were successfully treated, 64 cases died, with a mortality rate of 284%. Among them, 140 cases were MSOF and 58 cases died. The mortality rate was 41.4% Professor KnausWA professor MSOF diagnostic criteria, the group of 10 patients were eligible, the rescue success 52 cases, 54 deaths, the mortality rate was 50 9%. Conclusion: The combination of Chinese and Western medicine treatment of the Syndrome, the effect was significantly improved, is that Chinese medicine can improve the patient’s hemodynamics, hemorheology, nailfold microcirculation; affect cytokines, inflammatory mediators, thereby reducing systemic Inflammatory reaction, and can reduce the inhibition of gastrointestinal motility function, intestinal flora disorders and prevention of intestinal bacteria, endotoxin translocation; antioxidant protection of the role of cells