论文部分内容阅读
目的了解掌腱膜挛缩症(DUPUYIREN挛缩)的病理表现.方法采用免疫组化染色辅以计算机图像定量分析技术,对15例掌腱膜挛缩症患者的门侧病变掌腱膜及9例正常掌腱膜组织标本中的Ⅰ、Ⅲ型胶原和α－平滑肌肌动蛋白的表达进行检测,并用透射电镜观察病变掌腱膜组织的超微结构.结果病变掌腱膜组织中Ⅰ型胶原的表达低于正常对照组(P＜0.05);Ⅲ型胶原在病变组织中的表达略高于对照组(P＞005);α－平滑肌肌动蛋白在病变组织中的表达明显高于对照组(P＜0.01).在病变掌腱膜组织中存在有一种特化的肌纤维母细胞.结论肌纤维母细胞是掌腹膜挛缩症发病中最关键的病理因素.“,”Objective To investigate the pathological changes of Dupuytren’’s disease. MethodsStreptoavidin Peroxidase methods were applied to determine the expression level of type Ⅰ, Ⅲ collagen andα-SM actin in 17 hands of 15 patients and 9 hands of control samples of palmar aponeurosis. The ultrastructureOf lesioned aponeurosis was examined with electron microscope. Results The expression of type I collagenin the lesion was lower than that in normal aponeurosis (P