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糖尿病(DM)是以糖代谢失常的一种常见疾病,以高血糖为主要标志,其中I型糖尿病多发生于青少年,因胰岛素分泌缺乏,必须依赖胰岛素治疗。2型糖尿病多见于中老年人,主要由对胰岛素不敏感(即胰岛素抵抗)所致。自1992年第一个治疗DM的特效药物胰岛素问世以来,抗糖尿病药物的研发已取得长足进展,一些基于新的作用靶点的抗糖尿病药物已进入临床前或临床研究阶段。
Diabetes mellitus (DM) is a common disorder of glucose metabolism, with hyperglycemia as the main marker. Type I diabetes mostly occurs in adolescents. Insulin secretion is a must because of lack of insulin secretion. Type 2 diabetes is more common in the elderly, mainly due to insulin-insensitive (ie, insulin resistance) due. Since the advent of the first insulin-specific drug for the treatment of DM in 1992, advances in the development of antidiabetic drugs have been made. Some anti-diabetic drugs based on new targets have entered the preclinical or clinical research phase.