乙型肝炎及原发性肝癌患者sIL-2R的变化

• 作 者: 南月敏 王麟士 吴文娟 谢永富 庞英
• 机 构: 河南医科大学第三医院传染科
• 出 处: 新消化病学杂志
• 发表日期: 1997年05期
• 关键词: 乙型肝炎 sIL-2R 原发性肝癌 肝肿瘤 癌.肝细胞 肝炎.乙型 微机处理 白细胞介素 动态检测 中华传染病杂志

目的探讨ｓＩＬ２Ｒ水平与乙型肝炎病情的关系及其在原发性肝癌早期诊断中的价值．方法以ＥＬＩＳＡ法动态检测１１３例乙型肝炎及６例原发性肝癌患者ｓＩＬ２Ｒ水平，另选３１例健康体检者作对照组．结果以ｑ检验、ｔ检验进行统计学处理（微机处理，ＰＯＭＳ２００版）．结果各型乙型肝炎ｓＩＬ２Ｒ水平均显著高于正常对照（ＮＣ）组（Ｐ＜００１），其顺序依次为：ＨＣＣ＞ＣＳＨ＞ＣＨ（ＩＩ）＞ＬＣ＞ＣＨ（ＩＩ）＞ＡＨ＞ＣＨ（Ｉ）＞ＮＣ．ＨＣＣ组ｓＩＬ２Ｒ均值达正常值的２倍以上，且与ＣＨ（Ｉ），ＣＨ（Ｉ），ＡＨ间存在显著性差异（Ｐ＜００１，＜００５及＜００５）；ＣＨ（ＩＩ）组显著高于ＣＨ（Ｉ）组（Ｐ＜００１）．ＨＢｅＡｇ阳性组及ＨＢＶＤＮＡ阳性组ｓＩＬ２Ｒ水平显著高于阴性组．结论ｓＩＬ２Ｒ是监测乙型肝炎病情、ＨＢＶ复制及诊断早期原发性肝癌的一项敏感标志．

Objective To investigate the relationship between sIL2R level and hepatitis B status and its value in the early diagnosis of primary liver cancer. Methods The ELISA method was used to detect the level of sIL2R in 113 patients with hepatitis B and 6 patients with primary liver cancer. Another 31 healthy subjects were selected as the control group. The results of q test, t test for statistical analysis (PC, POMS2  00 version). Results The levels of sIL2R in all types of hepatitis B were significantly higher than those in the normal control (NC) group (P <001), and the order of HIL> CSH> CH (II)> LC> CH > CH (I)> NC. The mean value of sIL2R in HCC group was more than twice of the normal value, and there was significant difference with CH (I), CH (I) and AH (P <001, <005 and <005); The CH (II) group was significantly higher than the CH (I) group (P <001). HBeAg-positive group and HBVDNA-positive group sIL 2R levels were significantly higher than the negative group. Conclusion sIL 2R is a sensitive marker for monitoring the status of hepatitis B, HBV replication and early diagnosis of primary liver cancer.