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先前的临床试验表明,默克厂制造的乙肝疫苗有高水平的免疫原性。然而后来的研究证实,正常成人中的应答率低至68％。最近疾病控制中心和厂商的回顾性调查表明,抗体应答不良,可能与注射的解剖部位有关,即在臀部接种的应答率比在臂部(三角肌)接种低得多。20个血液透析中心的职员在上臂接种疫苗,其血清阳转率为93.9％,对照的23个中心的职员在臀部注射,阳转率则为81.0％。作者在一个区医院中的实践证实这结果,并且表明,
Previous clinical trials have shown that hepatitis M vaccines manufactured at Merck have high levels of immunogenicity. However, later studies confirmed that the response rate in normal adults as low as 68%. A recent retrospective survey by Centers for Disease Control and Prevention (CDC) and manufacturers showed that poor antibody response may be related to the anatomy of the injection, ie the rate of vaccination in the buttocks is much lower than in the arm (deltoid). 20 hemodialysis center staff in the upper arm vaccination, the seroconversion rate was 93.9%, 23 centers in the control staff in the buttocks, the positive rate was 81.0%. The authors’ practice in a district hospital corroborates this result and shows that,