论文部分内容阅读
目的了解人乳头瘤病毒感染与宫颈病变程度的关系。方法对本院近期内收治的716例妇科宫颈疾病患者采用杂交捕获法进行HPV检测。结果 716例妇科宫颈疾病患者中,慢性宫颈炎、宫颈癌前病变Ⅰ级、宫颈癌前病变Ⅱ~Ⅲ级和宫颈癌患者HPV检出阳性率分别为34.82%、59.77%、88.48%、100%;HPV检出含量(pg/ml)分别为(34.12±11.85)、(154.78±44.63)、(394.22±64.37)、(678.82±122.02)。不同类型病例的HPV检出阳性率差异有统计学意义(χ2=157.732,P<0.01);不同病例类型与HPV检出阳性率存在线性变化趋势(χ2=156.253,P<0.01);HPV阳性感染率与宫颈病变的程度呈正相关,HPV含量的高低与宫颈癌的发展存在密切关系。结论 HPV感染的检测对于临床诊断宫颈癌及癌前病变具有至关重要的临床意义。
Objective To understand the relationship between human papillomavirus infection and cervical lesions. Methods A total of 716 gynecological cervical diseases admitted to our hospital were examined by hybridization method. Results Among the 716 cases of gynecological cervical disease, the positive rates of HPV were 34.82%, 59.77%, 88.48%, 100% in patients with chronic cervicitis, grade Ⅰ cervical precancerous lesions, grade Ⅱ ~ Ⅲ cervical precancerous lesions and cervical cancer, respectively . The detected contents of HPV (pg / ml) were (34.12 ± 11.85), (154.78 ± 44.63), (394.22 ± 64.37) and (678.82 ± 122.02) respectively. The positive rate of HPV in different types of cases was statistically different (χ2 = 157.732, P <0.01). There was a linear trend in the positive rate of HPV among different types of cases (χ2 = 156.253, P <0.01) The rate of cervical lesions was positively correlated with the level of HPV levels and the development of cervical cancer are closely related. Conclusion The detection of HPV infection is clinically important for clinical diagnosis of cervical cancer and precancerous lesions.