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目的评价硬化剂消痣灵与无水乙醇联合应用对肝癌的局部治疗作用。方法8例巨块型肝癌于肝动脉化疗栓塞治疗后经皮穿刺瘤体内多点注入消痣灵20ml与无水乙醇10～20ml，每周1次，4～5次为1疗程。治疗期间观察.AFP、肿瘤大小的变化和B超影像学改变，并作随访。结果治疗后2例患者肿瘤缩小超过50％，5例缩小不足50％，1例不足25％，但发展延缓。有效率为88.8％。6mo、12mo和18mo累计生存率分别为88.8％、62.5％、25％。结论对介入治疗后仍不能手术切除的巨块型肝癌，消痣灵与无水乙醇局部注射对抑制和延缓肿瘤的发展近期效果明显。
Objective To evaluate the local therapeutic effect of the combined use of sclerotherapy agent Xiaozhiling and anhydrous ethanol on liver cancer. Methods Eight cases of massive hepatocellular carcinoma were treated with hepatic arterial chemoembolization. After injection, 20 ml of Xiaozhiling and 10 to 20 ml of anhydrous ethanol were injected into the punctured tumor. The treatment was performed once a week for 4 to 5 times. During treatment, AFP, changes in tumor size, and B-mode ultrasonographic changes were observed and followed up. Results After treatment, tumor shrinkage was more than 50% in 2 patients, less than 50% in 5 cases, and less than 25% in 1 case, but the development was delayed. The effective rate is 88.8%. The cumulative survival rates at 6 months, 12 months, and 18 months were 88.8%, 62.5%, and 25%, respectively. Conclusion For massive hepatocellular carcinoma, which can not be surgically removed after interventional therapy, the local injection of Xiaozhiling and anhydrous ethanol has obvious short-term effect on inhibiting and delaying the development of tumor.