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目的 观察青皮注射液对大鼠局灶性脑缺血再灌注损伤的脑保护作用。方法 采用大鼠局灶性脑缺血再灌注模型 ,32只大鼠随机分为对照组和青皮注射液治疗组 ;观察两组神经功能缺失体征评分和脑梗塞体积。结果 青皮组注射液组神经功能缺失评分为 (2 .1 30± 0 .991 )分 ,对照组为 (3 .1 30± 0 .756)分 ,青皮注射液组神经功能缺失体征评分明显低于对照组 (P <0 .0 5) ;青皮组注射液组对照组脑梗死体积为 (2 31 .85± 80 .1 4 )mm3,对照组为 (41 0 .81± 89.43)mm3,青皮注射液组脑梗死体积明显低于对照组 (P <0 .0 1 )。结论 青皮注射液对局灶性脑缺血再灌注损伤有明显的脑保护作用
Objective To observe the protective effect of Qingpi injection on focal cerebral ischemia-reperfusion injury in rats. Methods Focal cerebral ischemia-reperfusion model in rats was adopted. Twenty-two rats were randomly divided into control group and Qingpi injection treatment group. Neurological deficit score and cerebral infarction volume were observed in both groups. Results The score of neurological deficit in Qingpi injection group was (2. 130 ± 0.991) points, while the control group was (3. 130 ± 0.756) points. The score of neurological deficits in Qingpi injection group was significantly lower than (P <0.05). The volume of cerebral infarction in the Qingpi injection group was (21.385 ± 80.14) mm3 and that in the control group was (41 0.81 ± 89.43) mm3 Cerebral infarction volume in the fluid group was significantly lower than that in the control group (P <0.01). Conclusion Qingpi injection has obvious cerebral protective effect on focal cerebral ischemia-reperfusion injury