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冠状动脉性心脏病(冠心病)患者过高及过低的血压均可能与不良的预后有关,即J形曲线现象。血压较基线的变化与其脑卒中和心肌梗死风险的关系仍不清楚。在替米沙坦单用及与雷米普利联用全球终点试验的25 620例随机患者中,入选19 102例冠心病患者进行该研究。入选时血压为141/82 mm Hg(1mm Hg=0.133 kPa),随访期间血压平均降低7/6mm Hg。在校正一些潜在影响因素后,血压较基线降低34/21mm Hg与脑卒中风险降低有关,且心肌
Coronary heart disease (coronary heart disease) patients with high and low blood pressure may be associated with poor prognosis, the J-shaped curve phenomenon. The relationship between changes in blood pressure from baseline and their risk of stroke and myocardial infarction remains unclear. Of the 25,620 randomized patients who were given telmisartan alone and in combination with the global end point test for ramipril, 19,102 patients with coronary artery disease were enrolled in the study. Blood pressure at enrollment was 141/82 mm Hg (1 mm Hg = 0.133 kPa), with mean blood pressure reduction of 7/6 mm Hg during follow-up. After adjusting for a number of potential influencing factors, a decrease in blood pressure by 34/21 mm Hg from baseline was associated with a reduced risk of stroke and myocardial