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目的研究比较心肌肌钙蛋白I与肌酸激酶同工酶对急性心肌梗死的诊断价值。方法急性心肌梗死(AMI)患者45例,不稳定型心绞痛(UAP)患者42例,陈旧性心肌梗塞(OMI)患者47例,检测其血清中的肌钙蛋白I(cTnI)和肌酸激酶同工酶(CK-MB),cTnI>0.5ng/ml为阳性,CK-MB增高超过正常值为血清酶异常,对比观察三组患者的检测结果。结果AMI组cTnI检测为阳性结果的例数明显高于UAP组及OMI组(P<0.01)。cTnI诊断AMI的敏感性为100%(45/45),CK-MB为86.7%(39/45);cTnI诊断AMI的特异性为96.7%(86/89),CK-MB为55.1%(49/89)。cTnI检测的敏感性和特异性均明显高于CK-MB。结论cTnI对于诊断AMI较CK-MB具有更高的敏感性和特异性,且检测更方便、快捷,对AMI的诊断、鉴别诊断等具有重要意义,是一种新的更有价值的AMI诊断的特异性标志物。
Objective To compare the diagnostic value of cardiac troponin I and creatine kinase isoenzyme on acute myocardial infarction. Methods 45 patients with acute myocardial infarction (AMI), 42 patients with unstable angina pectoris (UAP) and 47 patients with old myocardial infarction (OMI) were studied for serum cTnI and creatine kinase CK-MB and cTnI> 0.5ng / ml were positive, CK-MB increased more than normal values for serum enzyme abnormalities, and compared the results of three groups of patients. Results The positive number of cTnI in AMI group was significantly higher than that in UAP group and OMI group (P <0.01). The sensitivity of cTnI in diagnosis of AMI was 100% (45/45) and CK-MB was 86.7% (39/45). The specificity of cTnI in diagnosing AMI was 96.7% (86/89) and CK-MB was 55.1% / 89). The sensitivity and specificity of cTnI detection were significantly higher than CK-MB. Conclusion cTnI is more sensitive and specific for the diagnosis of AMI than CK-MB, and it is more convenient and quicker to detect. It is of great significance to the diagnosis and differential diagnosis of AMI. It is a new and valuable diagnostic value of AMI Specific marker.