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目的 探讨转移相关基因 CD 44V3在甲状腺癌中的表达及其临床意义。方法 用免疫组织化学 S- P法 ,检测 40例甲状腺癌、2 0例甲状腺腺瘤和 1 0例正常甲状腺组织中 CD44V3基因蛋白的表达情况 ,并分析其与相关临床病理因素的关系。结果 CD44V3表达阳性率在甲状腺癌组显著高于腺瘤组和正常甲状腺组。有转移者 CD44V3阳性率高于无转移者 ,转移灶阳性率高于原发灶。CD44V3阳性表达与肿瘤大小、病理组织类型无关。结论 CD44V3与肿瘤浸润和转移相关 ,可作为预测肿瘤转移潜能的指标。
Objective To investigate the expression of metastasis related gene CD44V3 in thyroid carcinoma and its clinical significance. Methods The expression of CD44V3 protein in 40 cases of thyroid carcinoma, 20 cases of thyroid adenoma and 10 cases of normal thyroid tissue was detected by immunohistochemical S-P method. The relationship between CD44V3 and related clinicopathological factors was analyzed. Results The positive rate of CD44V3 in thyroid cancer was significantly higher than that in adenoma and normal thyroid. The positive rate of CD44V3 with metastasis was higher than that without metastasis, and the positive rate of metastasis was higher than that of primary tumor. The positive expression of CD44V3 was not related to tumor size and pathological type. Conclusion CD44V3 is associated with tumor invasion and metastasis and may be used as an indicator of tumor metastasis potential.