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HIV能感染易感的T细胞和单个核吞噬细胞。血中感染HIV的细胞总数(约1/400)和有效感染的亚群(约1/100 000)间有分离现象。已报告,血中所有感染的白细胞均为CD4~+T 细胞。中枢神经系统、淋巴结和肺中感染细胞数比血中高10000倍。它们不是CD4~+T 细胞而是Mφ。Mφ参与HIV 病的程度研究不多,但已注意到:(1)不同于CD4~+T 细胞的改变,患者血中单核细胞的数目、表型和功能甚至在疾病晚期改变都很少;(2)脑、淋巴结和肺中Mφ的有效感染
HIV can infect susceptible T cells and mononuclear phagocytes. There is a separation between the total number of HIV-infected cells in the blood (about 1/400) and the subpopulation of effectively infected (about 1/100 000). It has been reported that all the infected leukocytes in the blood are CD4 ~ + T cells. The number of infected cells in the central nervous system, lymph nodes and lungs is 10,000 times higher than in blood. They are not CD4 ~ + T cells but Mφ. However, it has been noticed that: (1) different from the changes of CD4 ~ + T cells, the number, phenotype and function of monocytes in the blood of patients are rarely changed even in later stage of disease; (2) Effective infection of Mφ in brain, lymph nodes and lung