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目的:观察桥本甲状腺炎女性患者血浆睾酮(T)以及白细胞雄激素受体(AR)的改变并探讨其意义。方法:选取桥本甲状腺炎患者20例,年龄21-54(43±6)岁,均为女性;对照组为健康女性20例,年龄18～50(40±5)岁。外周血白细胞AR测定采用放射配体结合法。同时检测血浆T的水平。结果:桥本甲状腺炎患者白细胞AR为(501±124)位点/细胞,显著低于对照组的(687±156)位
Objective: To observe the changes of plasma testosterone (T) and leukocyte androgen receptor (AR) in female patients with Hashimoto’s thyroiditis and to explore its significance. Methods: Twenty patients with Hashimoto’s thyroiditis were selected, aged 21-54 years (43 ± 6 years), all of whom were female. The control group consisted of 20 healthy women aged 18-50 years (40 ± 5 years). Peripheral blood leukocyte AR assay using radioligand binding method. Plasma T level was measured at the same time. Results: The leukocyte AR in Hashimoto’s thyroiditis patients was (501 ± 124) cells / cell, which was significantly lower than that in the control group (687 ± 156)