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从1984年～1990年2743例病人由于不同原因接受了三级中心的超声检查。发现288例胎儿有器官结构缺陷。在210例(73％)有先天异常的证据,并进行染色体分析,孕龄在11～38周,其余78例受累胎儿(27％)拒绝了细胞遗传学分析。作细胞遗传学研究的胎儿分成两组:一种和多种畸形。细胞遗传学研究标本40例于产前通过脐带穿刺,144例取羊水标本,16例取绒毛标本,10例孕38周者产后通过纤维母细胞或淋巴细胞培养。分娩后进一步再取新生儿皮肤或血标本加以证实。结果:288例畸形胎儿中发现41例(14％)核型异常,171例胎儿被检出1种结构异常者中,149
From 1984 to 1990, 2743 patients underwent three-stage ultrasonography for various reasons. Found 288 cases of fetal organ structural defects. In 210 patients (73%) with evidence of antecedent abnormalities and chromosomal analysis, gestational age ranged from 11 to 38 weeks, and the remaining 78 infants (27%) rejected cytogenetic analysis. Fetuses for cytogenetics are divided into two groups: one and many deformities. 40 cases of cytogenetics were prenatal umbilical cord puncture, 144 cases of amniotic fluid samples, 16 cases of villus specimens, and 10 cases of pregnant 38 weeks postpartum through fibroblasts or lymphocytes. Further confirmation of newborns’ skin or blood samples after childbirth. Results: Of the 288 abnormal fetal fetuses, 41 (14%) karyotypes were abnormal and 171 fetuses were detected as one of the structural abnormalities