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硬皮病的病因及发病机制尚未明确。关于其病因及发病机制有以下学说:遗传学说、自身免疫紊乱学说、细胞外间质代谢异常学说、血管病变学说、细胞因子异常学说。其中人类白细胞抗原基因与硬皮病的相关性是目前研究热点之一。HLA-Ⅰ、HLA-Ⅱ、HLA-Ⅲ类基因与硬皮病均有相关性。其中HLA-Ⅱ类基因中的HLA-DR、HLA-DQ与硬皮病的相关性最密切。
The etiology and pathogenesis of scleroderma is not yet clear. About the etiology and pathogenesis of the following theories: genetic theory, autoimmune disorders theory, abnormal extracellular matrix metabolism theory, vascular disease theory, abnormal cytokine theory. One of the human leukocyte antigen gene and scleroderma correlation is one of the current research hot spots. HLA-Ⅰ, HLA-Ⅱ, HLA-Ⅲ genes and scleroderma are related. HLA-DR and HLA-DQ are the most closely related to scleroderma.