聚苯乙烯磺酸钠减少铁吸收的效能

• 作 者: 冯锁平
• 出 处: 国外医学(医学地理分册)
• 发表日期: 1999年03期
• 关键词: 聚苯乙烯磺酸钠 血清铁 交叉试验 元素铁 体外模型 秩和检验 室分析 铁元素 胃肠症状 药物动力学

目的：评估聚苯乙烯磺酸钠（ＳＰＳ）减少铁吸收的能力。由于铁不与碳结合，故有必要寻求一种结合胃肠道铁的方法作为去污染措施。在一体外模型中显示按３５ｇＳＰＳ可对６５ｍｇ元素铁进行完全结合。在健康的志愿者中研究了ＳＰＳ阻止口服铁吸收的能力。方法：４例２８～４

Objective: To assess the ability of sodium polystyrenesulfonate (SPS) to reduce iron absorption. Since iron is not bound to carbon, it is necessary to find a method that combines the gastrointestinal tract iron as a decontamination measure. In an in vitro model, 65 mg of elemental iron was fully bound by 3  5gSPS. The ability of SPS to block oral iron absorption was studied in healthy volunteers. Methods: 4 cases 28 ~ 4