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对60例急性脑血管病并发应激性溃疡出血随机分为3组,观察洛赛克以静脉注射与胃管注射二种途径治疗同西米替丁对照治疗的疗效,并进行了用药前和用药5天后胃液pH值测定。结果:静脉注射和胃管注射洛赛克两组治疗急性脑血管病并发应激性溃疡出血,疗效相近,分别为95%和100%,二者总有效率97.5%,而西米替丁对照组总有效率35%,洛赛克与西米替丁两组间比较P<0.01。胃液测定在临床上证实了脑血管病并发应激性溃疡出血是以高胃酸分泌为特征的这一理论,胃液pH值由用洛赛克前1.70±0.46升至用药5天后的5.03±0.44,洛赛克静脉注射与胃管注射两组比较无显著差异(P>0.05),而用药前后自身比较P<0.01,对照组前后比较P<0.05,洛赛克组与对照组间比较P<0.05。
Sixty patients with acute cerebrovascular disease complicated with stress ulcer hemorrhage were randomly divided into three groups to observe the efficacy of Losec intravenous injection and gastric tube injection of two ways to treat with cimetidine control treatment, Gastric juice pH 5 days after treatment. Results: Intravenous and intragastric administration of Losec both in the treatment of acute cerebrovascular disease complicated by stress ulcer hemorrhage, similar efficacy was 95% and 100%, respectively, the total effective rate was 97.5%, while the cimetidine control Group total efficiency of 35%, Losec and cimetidine between the two groups were P <0.01. Gastric juice assay clinically confirmed that cerebrovascular disease complicated by stress ulcer bleeding is characterized by high gastric acid secretion, gastric pH value increased from 1.70 ± 0.46 before Losec to 5.03 ± 0.44 after 5 days of treatment, There was no significant difference (P> 0.05) between Losec intravenous injection and gastric tube injection, P <0.01 before and after treatment, P <0.05 before and after comparison, P <0.05 between Losec group and control group .