紫杉醇导致过敏反应一例

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患者男性,53岁,诊断为:鼻咽癌,入院后行化疗,方案为紫杉醇+冻干顺铂。按常规预防过敏反应处置后,将紫杉醇30 mg溶于葡萄糖100mL中静脉滴注,30滴/min缓慢静脉滴注,血压140/85mm Hg(1 mm Hg=0.133kPa),脉搏90次/min。输注10min后,患者突然出现烦躁不安、心悸、胸憋、气促。查体:口唇发绀,血压158/90mm Hg, Patients, male, 53 years old, diagnosed as: nasopharyngeal carcinoma, chemotherapy after admission, the program for paclitaxel + lyophilized cisplatin. According to the conventional prevention of allergic reactions, 30 mg of paclitaxel was dissolved in 100 mL of glucose and slowly dripped at 30 drops / min. The blood pressure was 140/85 mm Hg (1 mm Hg = 0.133 kPa) and the pulse rate was 90 beats / min. Infusion 10min, the patient suddenly appeared irritable, palpitations, chest choke, shortness of breath. Physical examination: cyanotic lips, blood pressure 158 / 90mm Hg,
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  过敏性紫癜 (HSP)是以全身毛细血管为主要病变的变态反应性疾病 [1, 2]。病理改变可波及全身多个脏器和系统。临床上除皮肤紫癜外,常有腹痛,关节痛及肾脏病变等 [1~3]。
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