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我院肺结核科于1980年6月20日14～15时,有42例肺结核病人相继主诉头晕、头痛、恶心、心慌,少数人呕吐。当时,经查体仅发现病人烦躁、脉快, 有些人血压升高。因当日11时半食咸鱼,曾考虑食物中毒。经调查,食鱼系腌青鱼,鱼质良好,烹调亦无异常。食同样食物的内外科病人无一例有反应。所以,当时对一般病人未作特殊处理,仅对较严重者投予异丙嗪、维生素B_6,对严重的3例输10%葡萄糖液1,000ml加维生素C2g,肌肉注射异丙嗪50mg等。当晚病人症状缓解,第二天症状消失。后经分析,发现反应者均为较长时间内接受异烟肼化疗者。据报道,腌青鱼系富含酪胺性的食物,而异烟肼对单胺氧化酶有抑制作用。根据这起反应的特点,可以认为是一起由异烟肼抑制单胺氧化的作用
Tuberculosis in our hospital at June 20, 1980 14 to 15, 42 cases of tuberculosis patients have complained of dizziness, headache, nausea, palpitation, a few vomiting. At that time, the body found only irritable, fast pulse, some people with elevated blood pressure. At 11:30 on the day due to eat salted fish, had considered food poisoning. After investigation, fish pickled herring, fish, good quality, cooking is no exception. None of the internal and external patients who ate the same food responded. Therefore, at that time, no special treatment for general patients, only for more serious promethazine, vitamin B_6, 3 cases of severe infusion of 10% glucose solution 1,000ml plus vitamin C2g, intramuscular injection of promethazine 50mg and so on. The patient’s symptoms relieved that night, the next day the symptoms disappeared. After the analysis, we found that responders were longer time to accept isoniazid chemotherapy. It is reported that salted herring is rich in tyramine-based foods, and isoniazid inhibits monoamine oxidase. According to the characteristics of this reaction can be considered together by the isoniazid inhibition of monoamine oxidation