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【目的】探讨细胞外基质金属蛋白酶诱导因子（CD147）和基质金属蛋白酶2（MMP‐2）在胆囊癌组织中的表达及意义。【方法】采用免疫组织化学法检测30例慢性胆囊炎和21例胆囊癌患者组织中CD147和M M P‐2的表达，并分析其临床意义。【结果】21例胆囊癌组织中 CD147和 M M P‐2的阳性表达率分别为71．4％（15／21）和76．2％（16／21），显著高于慢性胆囊炎组织中的表达13．3％（4／30）和23．3％（7／30）（ P ＜0．01）；CD147和M M P‐2的阳性表达与胆囊癌的临床分期和淋巴结转移显著相关（ P ＜0．05），且胆囊癌中CD147与MMP‐2的阳性表达呈正相关（ r ＝0．631，P ＝0．002）。【结论】CD147和MMP‐2在胆囊癌组织中的阳性表达与其临床分期和淋巴结转移相关，CD147可能通过与M M P‐2的相互作用共同参与调控胆囊癌的进展与转移。“,”[Objective] To explore the expressions of CD147 and matrix metalloprotease‐2 (MMP‐2) in tissues of chronic cholecystitis and gallbladder carcinoma and examine their clinical significance .[Methods]Immunohistochemistry was used for detecting CD147 and MMP‐2 in 30 chronic cholecystitis tissues and 21 gallbladder carcinoma tissues .And their clinicopathological data were analyzed .[Results] The expressions of CD147 and MMP‐2 was significant higher in 21 gallbladder carcinoma tissues [71 .4% (15/21)& 76 .2% (16/21)] than those in 30 chronic cholecystitis tissues [13 .3% (4/30)& 23 .3% (7/30)]( P<0 .01) .And the pos‐itive expressions of both were correlated with staging and lymph node metastasis ( P<0 .05) .The expressions of CD147 and MMP‐2 had a positive correlation in gallbladder carcinoma ( r =0 .631 ,P =0 .002) .[Conclu‐sion] The expressions of CD147 and MMP‐2 are positively correlated with staging and lymph node metastasis in gallbladder carcinoma .And CD147 may interact with MMP‐2 in regulating the progression of gallbladder carcinoma .