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目的 :探讨湖南地区系统性红斑狼疮患者的遗传易感性基因。方法 :运用PCR -SSO方法分析SLE患者和正常人群中HLADM基因的多态性。结果 :正常人群和SLE人群组中 ,DMA 0 10 1及DMB 0 10 1频率占主要地主 ,DMA 0 10 4和DMB 0 10 4为罕见基因 ,两组之间无显著性差异。结论 :湖南地区SLE患者中未发现HLADM易感基因。
Objective: To investigate the genetic predisposition genes in patients with systemic lupus erythematosus in Hunan province. Methods: PCR-SSO method was used to analyze the polymorphism of HLADM gene in SLE patients and normal controls. Results: The frequencies of DMA 0 10 1 and DMB 0 101 in the normal population and in the SLE population were dominated. DMA 0 10 4 and DMB 0 10 4 were rare genes, with no significant difference between the two groups. Conclusion: No HLADM susceptibility gene was found in SLE patients in Hunan Province.