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目的探讨氯吡格雷在血液净化(BP)患者股静脉置管血栓形成中的防治作用。方法将2004年4月至2007年10月解放军第59医院肾内科股静脉置管80例的BP患者分为两组,每组40例,对照组采用常规置管,治疗组采用常规置管后再服氯吡格雷片75mg/d,观察两组患者股静脉血栓形成发生率、凝血四项、血小板计数及血小板体积的变化。结果股静脉置管后下肢深静脉血栓发生率,对照组为17.6%,治疗组为2.6%,两组比较差异有统计学意义;凝血四项、血小板计数及血小板体积治疗前与治疗后相比,差异无统计学意义。结论氯吡格雷片可以降低BP患者股静脉置管后深静脉血栓发生率,且不影响凝血功能、血小板计数及血小板体积的变化。
Objective To investigate the preventive and therapeutic effect of clopidogrel on thrombosis of femoral vein in patients with blood purification (BP). Methods From April 2004 to October 2007, the BP patients of 80 cases of renal vein catheterization in the 59th Hospital of PLA were divided into two groups, 40 cases in each group. The control group was treated by conventional catheterization. The patients in the treatment group received conventional catheterization Clopidogrel tablets 75mg / d, were observed in two groups of patients with femoral vein thrombosis incidence, clotting four, platelet count and platelet volume changes. Results The incidence of deep venous thrombosis of the lower extremity after femoral vein catheterization was 17.6% in the control group and 2.6% in the treatment group, with significant difference between the two groups; four items of coagulation, platelet count and platelet volume before and after treatment ,The difference was not statistically significant. Conclusion Clopidogrel tablets can reduce the incidence of deep vein thrombosis after catheterization of femoral vein in BP patients without affecting the changes of coagulation function, platelet count and platelet volume.