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目的 探讨检测血清细胞质胸苷激酶(TK1)在直肠癌诊治中的临床价值.方法 利用增强化学发光法(ECLA)检测108例直肠癌患者(直肠癌组)血清TK1的含量,同时检测45例直肠良性疾病(良性疾病组)和48名健康人血清(正常对照组)中的TK1含量.结果 直肠癌组TK1水平为[2.45(1.27～3.85)pm/L],显著高于良性疾病组的[(1.25(0.76～1.45)pm/L]和正常对照组的[1.16(0.69～1.38)pm/L](P0.05).结论 血清TK1检测在直肠癌诊断方面具有一定的临床应用价值.“,”Objective To investigate the diagnostic value of serum thymidine kinase 1(TK1) in carcinoma of rectum. Methods The serum level of TK1 was determined by enhanced chemi-luminescence assay(ECLA) in 105 patients with carcinoma of rectum ( group A) ,45 cases with benign disease(group B) and 48 normal controls (group C). Results The level of TK1 was [2. 45(1. 27-3. 85) pm/L ] in group A, which was significantly higher than [1. 25(0. 76-1. 45) pm/L ] iri group B or than [1. 16(0. 69-1. 38) pm/L ] in group C (P0. 05). Conclusion The detection of TK1 has a certain value in the diagnosis of carcinoma of the rectum.