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目的加强对晚发性维生素K依赖性凝血因子缺乏的认识,总结该病的临床特点及发病原因,做到早预防、早发现、早期合理治疗。方法对泌阳县人民医院32例晚发维生素K依赖性凝血因子缺乏患儿的临床资料进行分析。结果 32例患儿中25例发生颅内出血,10例首发表现为针刺部位出血不止,5例首发表现为消化道出血。结论晚发性维生素K依赖性凝血因子缺乏是危害婴儿健康的常见出血性疾病之一,发病急,病死率高,合并颅内出血者致残率较高,应加强对乳母的营养指导,建立预防用药制度。
Objective To strengthen the understanding of the late vitamin K-dependent coagulation factor deficiency, summarize the clinical features and causes of the disease, and achieve early prevention, early detection and early rational treatment. Methods The clinical data of 32 children with late-onset vitamin K-dependent coagulation factor deficiency in Biyang County People’s Hospital were analyzed. Results Twenty-five children with intracranial hemorrhage occurred in 25 cases. The first episode of 10 cases showed bleeding in the acupuncture site and the onset of gastrointestinal bleeding in 5 cases. Conclusions Late onset vitamin K-dependent coagulation factor deficiency is one of the common hemorrhagic diseases that endanger the health of infants. The incidence of acute, high mortality and high morbidity of intracranial hemorrhage are higher. Nutritional guidance should be strengthened and prevention should be established Medication system.