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目的探讨碱性成纤维细胞生长因子(basic fibrob last growth factor,bFGF)在子宫内膜癌变组织中的表达情况,以及与子宫内膜癌的生长、浸润和转移的关系。方法通过免疫组织化学SP法,检测bFGF在正常子宫内膜(15例)、非典型增生子宫内膜(10例)及子宫内膜癌(50例)组织中的表达。结果(1)bFGF在正常子宫内膜、非典型增生子宫内膜及子宫内膜癌组织中的表达呈增高趋势,差异有统计学意义(P<0.05)。(2)bFGF强阳性表达与肿瘤病理分级、手术-病理分期、淋巴结有无转移均有显著相关性(P<0.05)。结论bFGF是子宫内膜癌组织重要的血管生成因子,其表达与肿瘤的生长、浸润及转移密切相关,可作为反映子宫内膜癌生物学行为的指标之一。
Objective To investigate the expression of basic fibroblast growth factor (bFGF) in endometrial cancerous tissue and its relationship with the growth, invasion and metastasis of endometrial carcinoma. Methods The expression of bFGF in normal endometrium (15 cases), atypical hyperplasia endometrium (10 cases) and endometrial carcinoma (50 cases) was detected by immunohistochemical SP method. Results (1) The expression of bFGF in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma showed an increasing trend, the difference was statistically significant (P <0.05). (2) The strong positive expression of bFGF has significant correlation with tumor pathological grade, operation-pathological stage and lymph node metastasis (P <0.05). Conclusions bFGF is an important angiogenic factor in endometrial carcinoma. The expression of bFGF is closely related to the growth, invasion and metastasis of endometrial carcinoma, which may be used as an index to reflect the biological behavior of endometrial cancer.