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AIM:To evaluate if HB vaccination can yield a booster effecton the anti-HBs level of those naturally acquired HBV positivemarkers.METHODS:Sera were collected from 1399 newly enrolleduniversity students aged between 18-20 years at theentrance medical examination in 2001.Forty-four students(28 males and 16 females) with positive serum anti-HBsand anti-HBc markers served as an observation group andanother 44 students (24 males and 20 females) without anyHBV markers as the control.HB vaccination was given to allthe students without positive serum HBsAg according to 0,1,6 month regimen and the peripheral venous blood wassampled from those of both observation and control groupsfor anti-HBs detection one month after the second and thirddoses.Anti-HBs levels were measured by ELISA.RESULTS:The seroconversion rate of anti-HBs in the controlgroup was 100% after the second dose,but the geometricmean titers (GMTs) were low.The tendency of serum anti-HBs changes after the 3~(rd) dose was completely differentbetween the two groups.Although more than half of thosewith positive anti-HBs and anti-HBc showed a mild increaseof anti-HBs levels after the 2~(nd) boosting dose (mean anti-HBs level was 320:198 mIU),but the increase of serumanti-HBs titer was much smaller than that in the controlgroup.The averages of their initial serum anti-HBs levelsand the levels after the 2~(nd) and 3~(rd) doses were 198,320 and275 mIU respectively.All the subjects from the control grouphad an obvious increase in their serum anti-HBs levels whichwas nearly 4 times the baseline level (302:78 mIU).CONCLUSION:HB vaccination can not enhance anti-HBs levelsin those with positive serum anti-HBs and anti-HBc markers.
AIM: To evaluate if HB vaccination can yield a booster effecton the anti-HBs level of those naturally acquired HBV positive markers. METHODS: Sera were collected from 1399 newly enrolleduniversity students aged between 18-20 years at theentrance medical examination in 2001. Forty-four students (28 males and 16 females) with positive serum anti-HBs and anti-HBc markers served as an observation group and another 44 students (24 males and 20 females) without any HBV markers as the control. HB vaccination was given to all the students without positive serum HBsAg according to 0, 1, 6 month regimen and the peripheral venous blood wassampled from those of both observation and control groups for anti-HBs detection one month after the second and third day. Anti-HBs levels were measured by ELISA .RESULTS: The seroconversion rate of anti-HBs in the control group was 100% after the second dose, but the geometric phenomenon (GMTs) were low. The tendency of serum anti-HBs changes after the 3 ~ (rd) dose was completely different between the two groups. Although more than half of those with positive anti-HBs and anti-HBc showed a mild increase of anti-HBs levels after the 2 ~ boosting dose (mean anti-HBs level was 320: 198 mIU), but the increase of serumanti-HBs titer was much smaller than that in the control group. The averages of their initial serum anti-HBs levels and the levels after the 2 ~ (nd) and 3 ~ (rd) doses were 198,320 and 275 mIU respectively. All the same subjects from the control grouphad an obvious increase in their serum anti-HBs levels which was nearly 4 times the baseline level (302: 78 mIU) .CONCLUSION: HB vaccination can not enhance anti-HBs levels in those with positive serum anti-HBs and anti- HBc markers.