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研究胆汁中胆汁酸的变化与胆色素结石形成的关系。方法结扎豚鼠的胆总管造成狭窄,一周后测定胆汁中胆汁酸及其它成分并行病理研究。结果狭窄组(S组)成石率达92.3%,均为胆色素结石(PS),胆汁中总胆红素(TBr)、非结合胆红素(IBr)、钙离子(ICa)、糖蛋白(GP)均较对照组(C组)明显升高总胆汁酸(TBA)也明显增高。S组胆汁中牛磺鹅脱氧胆酸(TCDCA)明显升高,而甘氨鹅脱氧胆酸(GCDCA)明显降低,G/T值显著下降。超微病理研究表明,S组肝细胞内线粒体明显肿胀,滑面内质网显著减少。结论胆汁G/T的下降与肝脏病变均有利于PS形成。
To study the relationship between bile acid changes and the formation of bile pigment stones. Methods Ligation of the common bile duct of guinea pig caused by stenosis. One week later, the bile acid and other components in the bile were assayed in parallel. Results The rate of stone formation in the stenosis group (S group) was 92.3%, all of which were biliary pigment (PS), total bilirubin (TBr), unconjugated bilirubin (IBr), calcium (ICa) (GP) were significantly higher than the control group (C group), total bile acid (TBA) was also significantly higher. In group B, TCDCA was significantly increased in bile, while GCDCA was significantly decreased and G / T was significantly decreased. Superfine pathological studies showed that the mitochondria in S group were obviously swollen and the endoplasmic reticulum was significantly reduced. Conclusions The decrease of G / T of bile and the pathological changes of liver all contribute to the formation of PS.