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目的探讨幽门螺杆菌(HP)~(13)C-尿素呼气试验(~(13)C-UBT)DOB值与反流性食管炎(RE)的相关性,评价根除HP治疗后RE的治疗效果。方法随机选择2016年1月~2016年12月在我院消化内科门诊就诊确诊为RE、~(13)C-UBT检测阳性(DOB值≥3.5dpm)的患者120例,回顾性分析其临床资料。患者分别按照Los Angeles分类(LA)法分级及按照临床症状严重程度评分,分析患者RE内镜分级及临床症状评分与DOB值的关系。再将120例患者按照1∶1比例随机分为观察组60例,给予根除HP治疗,对照组60例,给予常规治疗,疗程共8周。3个月后复查胃镜并行RE分级,记录两组患者临床症状缓解情况。结果 RE内镜分级与患者的DOB值水平呈负相关(P<0.01),RE临床症状评分与患者的DOB值水平呈负相关(P<0.01)。观察组60例患者治疗后复查~(13)C-UBT,52例阴性,8例阳性。观察组内镜下分级改善总有效率71.15%(37/52),高于对照组86.67%(52/60),P<0.05;观察组患者临床症状改善总有效率82.69%(43/52),与对照组88.33%(53/60)无明显差异,P>0.05。结论~(13)C-UBT的DOB值与患者内镜分级严重程度及临床症状评分呈负相关,HP感染可能是RE的保护因素。
Objective To investigate the correlation between the DOB value of Helicobacter pylori (HP) 13 C-urea breath test (~ (13) C-UBT) and reflux esophagitis (RE) effect. Methods A total of 120 patients with RE and ~ (13) C-UBT positive (DOB value ≥3.5dpm) were selected from the Department of Gastroenterology Clinics of our hospital from January 2016 to December 2016, and their clinical data were retrospectively analyzed . The patients were graded according to Los Angeles classification (LA) and scored according to the severity of clinical symptoms. The relationship between endoscopic grading and clinical symptom scores and DOB values was analyzed. Then 120 patients were randomly divided into observation group of 60 patients according to the ratio of 1: 1, given eradication HP treatment, control group of 60 patients, given conventional treatment, the course of treatment for a total of 8 weeks. Three months later, the patients underwent endoscopy and RE classification, and the clinical symptoms of both groups were recorded. Results The endoscopic grade of RE was negatively correlated with the level of DOB in patients (P <0.01). The clinical symptom score of RE was negatively correlated with the level of DOB in patients (P <0.01). After treatment, 60 patients in the observation group were reviewed for ~ (13) C-UBT, 52 were negative and 8 were positive. The total effective rate in observation group was 71.15% (37/52), which was higher than that in control group (86.67%, 52/60) (P <0.05). The total effective rate of observation group was 82.69% (43/52) , No significant difference with the control group 88.33% (53/60), P> 0.05. Conclusion The DOB value of ~ (13) C-UBT is negatively correlated with the severity of endoscopic grade and clinical symptom score, and HP infection may be the protective factor of RE.