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[目的]对因输血发生不良反应患者的临床特点进行调查,并分析其相关危险因素。[方法]对收治的9 825例输血患者临床资料实施回顾性分析,对因输血发生不良反应者的临床特点及不良反应情况进行统计。分别采用单因素描述和多因素logistic回归分析方法确定不良反应发生的危险因素。[结果]9 825例接受输血疗法的患者中共有108例发生不良反应,输血不良反应发生率为1.10%;含白细胞全血和悬浮红细胞输血不良反应发生率较高,分为1.42%和1.40%;输血不良反应相关危险因素按照危险程度由高到低依次为:过敏史(OR=5.897)、原发性血液病(OR=4.216)、体质量指数≥25 kg/m2(OR=3.267)、输血史(OR=2.430)和年龄≤18岁(OR=1.985),而白细胞滤除是输血不良反应的保护因素(OR=0.891)(P均<0.05或0.01)。[结论]应当针对存在高危因素者加强防范和监测,保障输血安全。
[Objective] To investigate the clinical features of patients with adverse reactions due to blood transfusion and analyze the related risk factors. [Methods] The clinical data of 9 825 transfused patients were retrospectively analyzed, and the clinical features and adverse reactions of patients with adverse reactions due to blood transfusion were analyzed. Single factor and multivariate logistic regression analysis were used to determine the risk factors for adverse reactions. [Results] A total of 108 out of 9 825 patients receiving transfusion therapy had adverse reactions and the incidence of transfusion adverse reactions was 1.10%. The incidence of transfusional adverse reactions with leukocyte whole blood and suspension erythrocytes was high, ranging from 1.42% to 1.40% The risk factors for adverse reactions of blood transfusion were as follows: the history of allergy (OR = 5.897), the primary blood disease (OR = 4.216), the body mass index ≥25 kg / m2 (OR = 3.267) Blood transfusion history (OR = 2.430) and age ≤18 years (OR = 1.985), while leukocyte filtration was the protective factor of transfusion adverse reactions (OR = 0.891) (all P <0.05 or 0.01). [Conclusions] Prevention and monitoring should be strengthened to ensure the safety of blood transfusion in the presence of risk factors.