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【目的】探讨泌尿系统感染患者病原菌的分布及耐药性。【方法】收集泌尿系统感染患者183例的尿液标本进行病原菌鉴定及大肠埃希菌体外药物敏感试验。【结果】泌尿系感染病原菌中革兰阴性杆菌占84．15％，革兰阳性球菌占14．21％，真菌占1．64％；居前3位的是大肠埃希菌（63．93％）、肺炎克雷伯菌（7．65％）、屎肠球菌（4．92％）。大肠埃希菌中超广谱β-内酰胺酶（ESBLs）阳性菌株70株，阳性率高达59．83％；大肠埃希菌对青霉素类和头孢菌素类耐药性较高，对碳青酶烯类保持高敏感性，对哌拉西林/他唑巴坦、呋喃妥因和阿米卡星耐药性较低。【结论】本院泌尿系统感染病原菌以大肠埃希菌为主，大肠埃希菌对青霉素类和头孢菌素类耐药性较高。“,”[Obj ective]To explore the pathogen distribution and drug resistance of patients with urinary system infection.[Methods]Urine specimens of 183 patients with urinary system infection were collected for pathogen iden-tification and Escherichia coli drug resistance in vitro.[Results]The infection rate of gram-negative bacilli,gram-posi-tive cocci and fungi in urinary system infection was 84.15%,14.21% and 1.64%,respectively.The top three pathogens were Escherichia coli(63.93%),klebsiella pneumonia(7.65%)and Enterococcus faecium(4.92%).There were 70 strains of Escherichia coli producing extended spectumβ-lactamases (ESBLs),which the positive rate was 59.83%.The drug resistance of Escherichia coli to penicillin and cephalosporins was higher,while the drug sensitivi-ty to carbapenem was higher,and the drug resistance to piperacillin/tazobactam,nitrofurantoin and amikacin was lower.[Conclusion]Escherichia coli is the most common pathogen in patients with urinary system infection of our hospital.The drug resistance of Escherichia coli to penicillin and cephalosporins is higher.