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目的:比较维药神香草水、醇提物及乙酸乙酯萃取物的镇咳、祛痰作用。方法:分别采用小鼠氨水引咳法、气管酚红排泄法考察其镇咳、祛疾作用。结果:阳性对照组和神香草不同提取物给药组对浓氨水致小鼠咳嗽反应有明显抑制作用,能延长小鼠咳嗽反应的潜伏(P<0.05),能明显提高小鼠呼吸道酚红排泌量(P<0.05)。其中神香草乙酸乙酯萃取物的作用更显著,并呈剂量依赖趋势(P<0.05)。结论:神香草乙酸乙酯萃取物镇咳、祛痰作用比其水、醇提取物更显著,推测神香草乙酸乙酯萃取物可能是其主要活性部位。
OBJECTIVE: To compare antitussive and expectorant effects of vanilloid water extract, alcohol extract and ethyl acetate extract. Methods: The mice induced by ammonia cough, tracheal phenol red excretion were investigated antitussive, dispel disease. Results: The positive control group and the different extracts of Shen vanilla had significant inhibitory effect on the cough response induced by concentrated ammonia water in mice, prolonged the latency of cough response in mice (P <0.05) Secretion (P <0.05). The Herbaceous extract of ethyl acetate more significant role, and a dose-dependent trend (P <0.05). CONCLUSION: The antitussive and expectorant effects of Herba Vanilla extract of ethyl acetate are more significant than those of water and alcohol extract. It is speculated that the extract of Herba Vannamei Ethyl Acetate may be the main active site.