HIV患者的浸润性外阴癌:病例报道及文献回顾

• 作 者: Elit L Voruganti S Simunovic M 侯巍
• 机 构: Department of Obstetrics and Gynecology McMaster University Juravinski Cancer Centre 699 Concession
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年10期
• 关键词: 浸润性外阴癌 文献回顾 外阴癌 病例 最佳治疗方案 高危型 文献报道 生殖道 细胞免疫 直肠癌

Background. HIV is associated with a decrease in cellular immunity which allows for persistence of high- risk HPV types and this can predispose the woman to dysplasia or cancer of the gynecologic tract. Case. We present a case of Stage 3 vulvar cancer in a 33- year- old HIV positive woman. The patient was treated with primary radiation; unfortunately there was persistent disease. Exenterative surgery was planned but abandoned due to a positive presacral node. Conclusion. The optimal treatment of advanced vulvar cancer in HIV positive patients remains unclear given the small number of cases reported in the literature. Lessons from the anal cancer literature may help inform the care of vulvar cancer patients given the comparable high prevalence of this disease in the patients infected with HIV.

Background. HIV is associated with a decrease in cellular immunity which allows for persistence of high- risk HPV types and this can predispose the woman to dysplasia or cancer of the gynecologic tract. Case. We present a case of Stage 3 vulvar cancer in a 33 - the-year- old HIV positive woman. The patient was treated with primary radiation; unfortunately there was persistent disease. Exenterative surgery was planned but dropped due to a positive presacral node. Conclusion. The optimal treatment of advanced vulvar cancer in HIV positive patients remains unclear given the small number of cases reported in the literature. Lessons from the anal cancer literature may help inform the care of vulvar cancer patients given the comparable high prevalence of this disease in the patients infected with HIV.