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豚鼠结肠带平滑肌存在肌源性分节律收缩，我们曾观察到中药大黄的有效成份大黄素（emodin，Emo）能加强该分节律收缩[1]。一氧化氮（NO）是非肾上腺素能非胆碱能（NANC）神经所释放的主要抑制性递质[2，3]，外源性NO可引起胃肠平滑肌细胞膜超极化和肌条舒张反应[4]。本文研究了
Guinea pig colon smooth muscle with myogenic rhythmic contractions, we have observed that the active ingredient of traditional Chinese medicine Rhubarb emodin (emodin, Emo) can strengthen the rhythm of contraction [1]. Nitric oxide (NO) is the major inhibitory neurotransmitter released by non-adrenergic non-cholinergic (NANC) nerves [2,3]. Exogenous NO induces membrane hyperpolarization and diastole in gastrointestinal smooth muscle cells [4]. ol