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目的前瞻性研究强化降糖和降压治疗对2型糖尿病大血管病变的影响。方法2001-07~2005-02,对江西医学院附属第三医院84例2型糖尿病患者进行随机、开放、对照研究。主要观察其大血管事件的发生情况。结果强化降糖、降压组,大血管事件发生明显减少,较一般降压和降糖组比较差异有显著性(P<0.01)。结论糖尿病并发高血压是一个具有复杂的、多因素构成的病理生理变化过程,较早干预和控制高血压和高血糖,对于预防大血管事件的发生,较单纯降糖和降压有较大意义。
Objective To prospectively study the effects of intensive hypoglycemic and antihypertensive treatment on macrovascular complications in type 2 diabetic patients. Methods From July 2001 to February 2005, 84 patients with type 2 diabetes mellitus in the Third Affiliated Hospital of Jiangxi Medical College were randomized, open and controlled. The main observation of the occurrence of major vascular events. Results The results of intensive hypoglycemic, antihypertensive and major vascular events were significantly lower than those of general antihypertensive and hypoglycemic groups (P <0.01). Conclusions Diabetes complicated with hypertension is a complex and multifactorial process of pathophysiological changes. Early intervention and control of hypertension and hyperglycemia are more significant than the mere hypoglycemic and antihypertensive drugs in preventing the occurrence of macrovascular events .