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探讨在耳蜗功能早期轻微损害时畸变产物耳声发射（ＤＰＯＡＥ）幅值及频谱时间序列的特征，促进ＤＰＯＡＥ的临床应用。方法：用 １３０ｄＢ ＳＰＬ的 ４ ｋＨｚ纯音对 １５例听力正常人（３０耳）进行 ３ ｍｉｎ的短时暴露，造成听力暂时性阈移后，用ＩＬＯ－９０耳声发射仪记录、分析暂时性阈移（ＴＴＳ）时ＤＰＯＡＥ的幅值、时间序列的特征，并与纯音暴露前进行对比。结果：正常人经过短时纯音暴露后，０．５，１，２ ｋＨｚ纯音和宽带噪声的声反射阈升高，纯音暴露前后０．５、１、２ ｋＨｚ与ＢＢＮ之间的平均反射阈差值分别为（９．７８±６．９８），（８．０４±５．５８），（１３．０±５．５８） ｄＢ ＨＬ和（８．８２±６．２３），（５．７５±４．４２），（９．０５±２．２７）ｄＢ ＨＬ，声反射阈差值缩小。纯音暴露前后６ ｋＨｚＤＰＯＡＥ幅值分别为（６．００±３．４５）和（１．７２±１. ２３） ｄＢ ＳＰＬ，降低４．２８ ｄＢ ＳＰＬ，时间序列变异系数为（５．１８±１．６３）％，时间序列曲线稳定性降低，ＤＰＯＡＥ幅值与时间序列结合发现８０％的人ＤＰＯＡＥ处于异常范围。结论：ＤＰＯＡＥ的幅值与时间序列结合分析有诊断耳蜗功能早期轻微受损的临床价值。
To investigate the characteristics of distortion product otoacoustic emissions (DPOAE) amplitude and time series in the early stage of mild cochlear damage, and to promote the clinical application of DPOAE. Methods: Short-term exposure of 15 normal hearing people (30 ears) for 3 min with 4 kHz pure tones of 130 dB SPL resulted in a transient threshold shift of hearing and was recorded with an ILO-90 otoacoustic transmitter. The transient threshold shift (TTS) DPOAE amplitude, time series characteristics, and compared with pure tone before exposure. Results: After pure short-term pure tone exposure, the acoustic reflex threshold of pure tone and broadband noise of 0.5, 1, 2 kHz increased, and the average reflex threshold difference between 0.5, 1, 2 kHz and BBN before and after pure tone exposure (9.78 ± 6.98), (8.04 ± 5.58), (13.0 ± 5.58) dB HL and (8.82 ± 6.23), (5.75 ± 4.42), (9.05 ± 2.27) dB HL, the acoustic reflex threshold is reduced. The 6 kHz DPOAE amplitudes before and after pure tone exposure were (6.00 ± 3.45) and (1.72 ± 1.23) dB SPL, respectively, decreasing by 4.28 dB SPL with a time series coefficient of variation of (5.18 ± 1. 63%), the stability of the time series curve is reduced, DPOAE amplitude and time series found that 80% of the people DPOAE in the abnormal range. Conclusion: The combined detection of amplitude and time series of DPOAE has the clinical value of diagnosing early mild damage of cochlear function.