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Purpose:To determine whether conjunctival biopsy in the offspring of patients with exfoliation syndrome(XFS)can provide early diagnosis of the disease.Methods:Patients with XFS with or without glaucoma were invited to ask their sons and daughters over the age of 40 years to participate in the study.After a complete eye examination,those without clinically evident XFS underwent conjunctival biopsy.The specimens were examined by transmission electron microscopy.Results:A total of 17 sons and daughters(seven men,10 women)of 17 patients were enrolled.Their mean age was 50.3± 8 years.Twelve specimens were negative and five presented precursor material evidence of typical exfoliationmaterial.Conclusion:Evidence of early deposition of exfoliation material can be found in the conjunctiva of the middle-aged offspring of patients with XFS,substantiating the existence of a hereditary predisposition to this disease.
Purpose: To determine whether conjunctival biopsy in the offspring of patients with exfoliation syndrome (XFS) can provide early diagnosis of the disease. Methods: Patients with XFS with or without glaucoma were invited to ask their sons and daughters over the age of 40 years to participate in the study. After a complete eye examination, those without clinically evident XFS underwent conjunctival biopsy. The specimens were examined by transmission electron microscopy. Results: A total of 17 sons and daughters (seven men, 10 women) of 17 patients were enrolled .Their mean age was 50.3 ± 8 years.Twelve specimens were negative and five presented precursor material evidence of typical exfoliation material. Conflusion: Evidence of early deposition of exfoliation material can be found in the conjunctiva of the middle-aged offspring of patients with XFS, substantiating the existence of a hereditary predisposition to this disease.