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目的探讨AEG-1在大肠癌中的表达及其临床病理意义。方法采用免疫组化的方法检测60例正常大肠粘膜、22例大肠腺瘤和60例大肠腺癌中AEG-1的表达。结果大肠腺癌和腺瘤中AEG-1的阳性率分别为91.7%和90.9%,明显高于正常大肠粘膜组织的23.3%,两者之间差异有统计学意义(P<0.001),其中大肠腺癌的中度阳性率和强阳性率分别为31.7%和60%,而大肠腺瘤分别为63.6%和27.3%,两者差异具有统计学意义(P=0.019);对大肠腺癌中AEG-1表达与肿瘤临床病理特征做相关性分析,结果表明,AEG-1表达强度与肿瘤T、N分期显著正相关(P<0.05)。结论 AEG-1在大肠癌和大肠腺瘤中表达增强,在大肠腺瘤恶变、大肠癌发生发展过程中发挥重要作用,可作为诊断大肠癌新的生物标记物。
Objective To investigate the expression of AEG-1 in colorectal carcinoma and its clinicopathological significance. Methods Immunohistochemical method was used to detect the expression of AEG-1 in 60 cases of normal colorectal mucosa, 22 cases of colorectal adenoma and 60 cases of colorectal adenocarcinoma. Results The positive rates of AEG-1 in colorectal adenocarcinoma and adenoma were 91.7% and 90.9%, respectively, which were significantly higher than those in normal colorectal mucosa (23.3%, P <0.001) The positive rate and strong positive rate of adenocarcinoma were 31.7% and 60% respectively, while those of colorectal adenomas were 63.6% and 27.3%, respectively (P = 0.019). The positive rates of AEG 1 expression and clinicopathological features of the tumor do correlation analysis, the results showed that AEG-1 expression intensity and tumor T, N stage was significantly correlated (P <0.05). Conclusion The expression of AEG-1 in colorectal carcinoma and colorectal adenoma is increased, which plays an important role in the carcinogenesis and progression of colorectal adenoma. It may serve as a new biomarker for the diagnosis of colorectal cancer.