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已知,在成年雄性恒河猴,皋酮似为调节LH和FSH分泌的负反馈环路中的主要性腺成分.但睾酮对促性腺激素分泌的抑制作用的机理尚未弄清.在多种哺乳类动物,LH的分泌呈现周期性,这是下丘脑间断性释放GnRH的结果.据此,可以用检查在人为改变循环睾酮浓度时对LH释放的脉冲型式,特别是对脉冲频率的影响,来阐明睾酮负反馈作用的神经内分泌机理.本文即观察了在完整恒河猴、双侧睾丸切除后的动物,以及阉割后用睾酮取代治疗的动物,循环LH浓度的变化.
It is known that adult male rhesus monkey is a major gonadal component in the negative feedback loop that regulates the secretion of LH and FSH, but the mechanism by which testosterone inhibits gonadotropin secretion has not yet been clarified, The secretion of LH appears to be periodic in animals, as a result of the intermittent release of GnRH from the hypothalamus, by which it is possible to examine the effects of the pulse pattern on the release of LH, in particular on the pulse frequency, when artificially changing the circulating testosterone concentration To clarify the neuroendocrine mechanism of testosterone negative feedback.This article was observed in the complete rhesus monkeys, bilateral orchiectomy animals, and testosterone after castration treatment of animals treated with changes in circulating LH concentration.