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目的:探讨混合核苷片与甲巯咪唑合用治疗甲亢的疗效及混合核苷对甲巯咪唑相关副作用的影响。方法:在使用甲巯咪唑治疗甲亢的基础上,将患者随机分为加用混合核苷片(治疗组)或复合维生素B(对照组),比较两组治疗1年过程中甲状腺功能变化及白细胞减少症、粒细胞缺乏症、肝功能损害及皮疹等发生情况。结果:治疗组的第一、二次减药时间明显短于对照组(P<0.05);治疗1年后治疗组没有达到维持剂量的患者明显少于对照组(P<0.05);治疗前3个月治疗组白细胞数和中性粒细胞绝对数均高于对照组,其白细胞减少病人数明显少于对照组(P<0.05));两组肝功能损害及皮疹的发生率无明显差异(P>0.05)。结论:混合核苷片和甲巯咪唑合用治疗甲亢,能帮助甲状腺功能较快恢复,并可减少甲巯咪唑治疗过程中白细胞减少和粒细胞缺乏的发生。
Objective: To investigate the curative effect of combined nucleoside tablets and methimazole in the treatment of hyperthyroidism and the effect of mixed nucleosides on the side effects of methimazole. Methods: On the basis of the treatment of hyperthyroidism with methimazole, the patients were randomly divided into mixed nucleoside tablets (treatment group) and multivitamin B (control group). The changes of thyroid function and leukocyte Reduce disease, agranulocytosis, liver damage and rash and other occurrences. Results: The first and second subtraction time of the treatment group was significantly shorter than that of the control group (P <0.05). The treatment group did not reach the maintenance dose one year after treatment was significantly less than the control group (P <0.05); before treatment 3 The number of white blood cells and neutrophils in the treatment group were higher than those in the control group, and the number of leukopenia patients in the treatment group was significantly less than that in the control group (P <0.05). There was no significant difference in the incidence of liver dysfunction and rash P> 0.05). Conclusion: The combination of nucleoside tablets and methimazole in the treatment of hyperthyroidism can help the thyroid function to recover quickly and reduce leukopenia and agranulocytosis in the course of methimazole treatment.