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目的 探讨血清透明质酸（ Ｈ Ａ） 、Ⅲ型前胶原（ ＰⅢ Ｐ） 、Ⅳ型胶原（ Ｃ Ｉ Ｖ） 联合检测在病毒性肝炎肝纤维化发生、发展及治疗过程中的临床意义。方法 利用 Ｒ Ｉ Ａ 法对病毒性肝炎患者（２１２ 例） 、正常对照组（８３ 例） 进行 Ｈ Ａ、 ＰⅢ Ｐ、 Ｃ Ｉ Ｖ 含量测定。两组均数差异显著性分析采用ｔ 检验。结果 肝炎患者３ 项指标与正常对照组比较差异有显著意义（ Ｐ＜ ０ ．０１） ，并且浓度随慢性迁延性肝炎（ Ｃ Ｐ Ｈ） →慢性活动性肝炎（ Ｃ Ａ Ｈ） →肝硬化（ Ｌ Ｃ） 逐渐升高（ Ｐ＜ ０ ．０５） 。结论 Ｈ Ａ、 ＰⅢ Ｐ、 Ｃ Ｉ Ｖ 多指标联合检测对肝病的诊断、病情观察、判定疗效及预后有重要意义；对 Ｃ Ｐ Ｈ 和 Ｃ Ａ Ｈ 的鉴别诊断具有一定价值。
Objective To investigate the clinical significance of combined detection of serum hyaluronic acid (H A), type Ⅲ procollagen (P Ⅲ P) and type Ⅳ collagen (C I V) in the pathogenesis, development and treatment of hepatic fibrosis in viral hepatitis. Methods R A A method was used to detect H A, P Ⅲ P and C I V in patients with viral hepatitis (212 cases) and normal control group (83 cases). Significant analysis of mean difference between the two groups using t test. Results There were significant differences between the three indexes of hepatitis patients and the normal control group (P <0.01), and the concentrations were significantly different between chronic persistent hepatitis (C P H) → chronic active hepatitis (C A H) → cirrhosis C) increased gradually (P <0 .05). Conclusion The combined detection of H A, P Ⅲ P and C I V is of great significance in the diagnosis of liver disease, observation of disease, curative effect and prognosis of hepatopathy. It has certain value in the differential diagnosis of C P H and C A H.