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目的观察和评价阿泰宁(含酪酸梭菌CGMCC NO.0313-1株)治疗肠易激综合征(IBS)的临床疗效。方法对符合罗马Ⅱ诊断标准的IBS患者,用阿泰宁胶囊口服,1次3粒,1天2次,疗程14~21 d。治疗期间观察患者的症状变化、服药情况,治疗结束后评价药物的疗效。结果50例IBS患者治疗后的腹泻或便秘等症状有显著的改善(P<0.05)。治愈率为62%(31/50),总有效率为94%(47/50),治疗中未见不良反应或副作用。结论阿泰宁是治疗IBS的一种安全有效的微生态药品,不但短期应用效果好,而且慢性腹泻或便秘患者可长期服用。
Objective To observe and evaluate the clinical efficacy of Artenin (Clostridium butyricum CGMCC NO.0313-1 strain) in the treatment of irritable bowel syndrome (IBS). Methods Patients with IBS meeting the diagnostic criteria of Rome II were treated with Atenin capsules orally once a day for 3 to 14 days for 21 days. Observed during treatment of patients with symptoms, medication, evaluation of the efficacy of the drug after the treatment. Results The symptoms of diarrhea or constipation in 50 IBS patients were significantly improved (P <0.05). The cure rate was 62% (31/50) and the total effective rate was 94% (47/50). No adverse reactions or side effects were observed during the treatment. Conclusion A Taining IBS is a safe and effective treatment of probiotics, not only short-term effect is good, but chronic diarrhea or constipation patients can take long-term.