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合成了一种新型可聚合型含钆单体,在温敏单体N-异丙基丙烯酰胺存在下,采用无皂乳液聚合法一步制备了含钆温度敏感的高分子微球.透射电子显微镜测试表明微球呈单分散性;动态光散射测试表明高分子微球的平均水合粒径约260 nm,呈现很窄的粒径分布;当温度从25℃升到45℃时,其粒径减小约60 nm,表明含钆高分子微球具有较好的温度敏感性.体外MRI测试表明,所得高分子微球的体外弛豫率为8.01(mmol/L)-1S-1(3 T),能有效的增强MRI信号,具有优良的MRI造影功能.上述结果表明,所得微球作为一种多功能MRI造影剂,在生物医学领域极具应用前景.
A novel polymerizable gadolinium-containing monomer was synthesized and the temperature-sensitive gadolinium-containing polymer microspheres were prepared in one step by soap-free emulsion polymerization in the presence of the temperature-sensitive monomer N-isopropylacrylamide. Transmission electron microscopy The results showed that the microspheres were monodispersed. The dynamic light scattering test showed that the average hydrated diameter of the polymer microspheres was about 260 nm, showing a very narrow particle size distribution. When the temperature was raised from 25 ℃ to 45 ℃, About 60 nm, indicating that the gadolinium-containing polymer microspheres have better temperature sensitivity.In vitro MRI test showed that the in vitro relaxation rate of the obtained polymer microspheres was 8.01 (mmol / L) -1S-1 (3 T) , Which can effectively enhance the MRI signal with excellent MRI imaging.The above results show that the resulting microspheres as a multifunctional MRI contrast agent, has great potential in the field of biomedical applications.