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目的:评价抗结核药物早期规范治疗糖尿病伴肺结核患者抗结核的临床疗效。方法:选取2014年2月—2016年2月间收治的老年糖尿病伴肺结核患者80例的临床资料,按照入院顺序抽签后将其随机分为治疗组和对照组,每组40例;对照组患者给予半合成人胰岛素和吡格列酮治疗,治疗组患者在对照组基础上给予抗结核药物早期规范抗结核治疗,评价两组患者治疗后的总有效率、治疗前后血糖各指标测得值、痰菌转阴及病灶改善情况以及治疗后结核症状的缓解情况。结果:治疗组患者治疗后的总有效率为95.00%高于对照组为72.50%(P<0.05);治疗后FBG、2 h PBG测得值低于同组治疗前(P<0.05);治疗组患者治疗后FBG、2 h PBG测得值均显著低于对照组(P<0.05);痰菌转阴率及病灶的缩小率均高于对照组(P<0.05);结核症状复常时间、肺功能指标复常时间以及抗结核药物用药时间均显著低于对照组(P<0.05)。结论:老年糖尿病伴肺结核患者采用抗结核药物早期规范治疗可显著提高临床疗效和血糖控制效果,促进痰菌转阴和病灶改善。
OBJECTIVE: To evaluate the clinical efficacy of anti-tuberculosis drugs in the early normative treatment of anti-tuberculosis patients with diabetes mellitus and pulmonary tuberculosis. Methods: The clinical data of 80 elderly patients with diabetes mellitus and pulmonary tuberculosis who were admitted from February 2014 to February 2016 were selected and randomly divided into treatment group and control group according to admission order, 40 cases in each group. Patients in the control group Given semi-synthetic insulin and pioglitazone treatment, patients in the treatment group were given anti-tuberculosis drugs early standard anti-TB treatment on the basis of the control group, to evaluate the total effective rate of the two groups after treatment, before and after treatment the measured values of blood glucose, Yin and lesions to improve the situation and the relief of tuberculosis symptoms after treatment. Results: After treatment, the total effective rate of treatment group was 95.00%, which was significantly higher than that of control group (72.50%, P <0.05) (P <0.05). The negative conversion rate of the sputum and the reduction rate of the lesions were higher than those of the control group (P <0.05). The recovery time of tuberculosis symptoms , Pulmonary function parameters of the normal time and anti-TB drugs were significantly lower than the control group (P <0.05). Conclusion: Elderly patients with diabetes mellitus and tuberculosis treated with anti-tuberculosis drugs can significantly improve the clinical efficacy and blood sugar control effect, and promote the sputum negative and improve the lesions.