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清醒家兔静注吡喹酮45mg/kg后,心律失常发生率为76.5％。侧脑室注入吡喹酮3mg/kg后78.9％的兔出现与静注时性质相同的心律失常。从椎动脉注入苯妥英钠3mg/kg能即刻对抗静注吡喹酮所致的心律失常。毁坏双侧肾上腺體质,利血平化及中枢应用心得安后,吡喹酮侧脑室注射所致心律失常发生率显著降低。中枢应用心得安及心得宁后,吡喹酮静注所致心律失常发生率也显著降低,但椎动脉注射可乐宁却无效。吡喹酮引起心律失常可能与中枢β受体兴奋而导致肾上腺髓质分泌肾上腺素及交感神经释放去甲肾上腺素有关。
After conscious rabbits were injected with praziquantel 45mg / kg, the incidence of arrhythmia was 76.5%. After injection of praziquantel 3 mg / kg into the lateral ventricle, 78.9% of the rabbits developed the same type of arrhythmias during intravenous injection. Infusion of phenytoin from the vertebral artery 3mg / kg immediately against intravenous injection of praziquantel-induced arrhythmia. Destroying bilateral adrenal gland, reserpine and central application of propranolol, praziquantel significantly reduced the incidence of arrhythmia caused by intraventricular injection. Central application of propranolol and experience Ning, praziquantel intravenous induced arrhythmia incidence was significantly reduced, but the injection of clonidine in the vertebral artery was ineffective. Praziquantel-induced arrhythmia may be related to the central beta receptor excitability leading to adrenaline secretion by the adrenal medulla and sympathetic nerve release of norepinephrine.