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目的：：探讨术前口服双歧杆菌乳杆菌三联活菌片对心脏瓣膜置换术后肝肠功能的作用，比较手术后发生肝肠功能障碍的发生率。方法：采用随机、单盲药物对照研究方法。入选2015年6月至2016年6月四川省人民医院160例的风湿性心脏瓣膜病患者。采用随机数字表法分为试验组和对照组。对照组接受常规术前准备（n=80），试验组在此基础上口服3天双歧杆菌乳杆菌三联活菌片(n=80)。结果：与对照组相比，双歧杆菌乳杆菌三联活菌片口服3天术后的高胆红素血症发生率降低（10% vs.22.5%，P=0.032），腹泻及便秘发生率降低(P=0.028)。结论：术前口服双歧杆菌乳杆菌三联活菌片有助于降低体外循环心脏手术后患者的肝肠功能障碍反应发生率。“,”Objective To investigate the efifcacy of oral live combined biifdobacterium and lactobacillus tablets in rheumatic heart valves patients undergoing valve(s) replacement on cardiopulmonary bypass, the liver and intestinal function after treatment were compared. Methods One hundred sixty patients undergoing valve(s) replacement procedures, were randomly selected for the study. In the experiment group, treatment was given additional oral live combined biifdobacterium and lactobacillus tablets for three days. Total bilirubin was measured preoperatively and at 72 hours, following valve(s) replacement procedure. Postoperative incidence rate of diarrhea or constipation was compared by chi-square test. The level of the biomarker for systemic inlfammation was compared with t test. Results There were lower incidence rate of hyperbilirubinemia in experimental group than that in control group (10% vs. 22.5%,P=0.032). There were lower incidence rate of diarrhea or constipation in experimental group than these in control group (P=0.028). Conclusion Treatment with additional oral live combined biifdobacterium and lactobacillus tablets for three days in patients with rheumatic valve disease decreased the postoperative incidence rate of liver and intestinal dysfunction.