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支气管哮喘(以下简称哮喘)是由多种细胞及细胞组分参与的慢性气道炎性疾病,以呼吸道炎性反应、气道高反应性、气道重塑为其主要特征,是当前世界面临的重要健康问题,其发病率和病死率在逐年上升。哮喘黏液高分泌与气道重塑有关,是哮喘气道上皮杯状细胞增生和黏膜下腺体肥大等病理生理变化的结果[1]。黏液高分泌导致气道阻塞、肺功能下降和感染增加是严重哮喘发作面临的首要问题。尽管目前药物治疗对
Bronchial asthma (hereinafter referred to as asthma) is a chronic airway inflammatory disease involving a variety of cells and cell components, with respiratory inflammatory response, airway hyperresponsiveness and airway remodeling as its main features, is the current world facing Of the major health problems, the morbidity and mortality are increasing year by year. Asthmatic mucus hypersecretion is associated with airway remodeling as a result of pathophysiological changes such as goblet cell proliferation and submucosal gland hypertrophy in asthmatic airways [1]. Mucosal hypersecretion leading to airway obstruction, decreased lung function and increased infection is the primary problem facing severe asthma attacks. Despite the current drug treatment right