【摘 要】
：
During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessi
【机 构】
：
Department of Biology, University of Dayton, Dayton, OH, USA;Medical Candidate, University of Toledo
论文部分内容阅读
During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas excessive cell deathresults in neurodegenerative disorders. Many signaling pathways known-to-date have a role in growth regulation. Among them, evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and development. Neurodegeneration, a complex process of progressive death of neuronal population, results in fatal disorders with no available cure to date. During normal development, cell death is required for sculpting of an organ. However, aberrant cell death in neuronal cell population can result in neurodegenerative disorders. Hippo pathway has gathered major attention for its role in growth regulation and cancer, however, other functions like its role in neurodegeneration are also emerging rapidly. This review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo pathway. Understanding Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.
其他文献
Administration of platelet rich plasma (PRP) and bone marrow aspirate concentrate(BMAC) has shown some promise in the treatment of neurological conditions; however, there is limited information on combined administration. As such, the purpose of this stud
The baker\'s yeast Saccharomyces (S.) cerevisiae is a single-celled eukaryotic modelorganism widely used in research on life sciences. Being a unicellular organism, S. cerevisiae has some evident limitations in application to neuroscience. However, yeas
Neuroprotection studies have shown that induced pluripotent stem (iPS) cells have the possibility to transform neuroprotection research.In the present study, iPS cells were generated from human renal epithelial cells and were then differentiated into neur
Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer\'s disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this revi
Metabolic rewiring and deregulation of the cell cycle are hallmarks shared by manycancers. Concerted mutations in key tumor suppressor genes, such as PTEN, and oncogenes predispose cancer cells for marked utilization of resources to fuel accelerated cell
Sepsis and the blood-brain barrier (BBB):rnSepsis is a life threatening systemic inflammatory condition involving multi-organ dysfunction. The World Health Organization estimates that about 30 million people are affected by sepsis every year, and at least
A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define
Subcortical ischemic white matter injury (SIWMI), pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging, is a common causeof cognitive decline in elderly. Despite its high prevalence, it remains unknown how
Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of injury. Peripheral myelinating glia, Schwann cells (SCs), interact with various ce
Intraspinal inflammatory and immune responses are considered to play central roles in the pathological development of spinal cord injury.This study aimed to decipher the dynamics of systemic immune responses, initiated by spinal cord injury. The spinal co